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Agenus Secures $340 Million to Pivot Toward Colon Cancer Trials

Agenus is betting its future on a late-stage colon cancer treatment, securing up to $340 million through a private equity placement. The Lexington-based immuno-oncology firm plans to shift its clinical focus, prioritizing a new phase 3 trial while cutting funding for existing metastatic cancer research.

Agenus Secures $340 Million to Pivot Toward Colon Cancer Trials

The financing consists of $85 million in upfront gross proceeds, with an additional $255 million contingent on the full exercise of purchase warrants. Investors responded positively to the news, pushing Agenus shares up 16% to $3.87 in premarket trading. The transaction, led by Commodore Capital with participation from firms including RA Capital Management and Ligand Pharmaceuticals, is expected to close around Wednesday.

With this capital, the company intends to launch the Robbin trial, a registrational phase 3 study focusing on botensilimab and balstilimab for the neoadjuvant treatment of microsatellite-stable colon cancer. To concentrate resources on this effort, Agenus will discontinue financial support for its ongoing Battman Phase 3 study, which targets late-line metastatic colorectal cancer. The company structured the deal at a premium to Friday’s closing price, signaling confidence in its reoriented pipeline.

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